The start of the £10.95 million work on Junction 29 of the M5 begins with a turf cutting ceremony at 11.30am on Monday, May 23.
The project will also construct a new link road to the old A30 (the C832) at Blackhorse, which will include junctions into the new Exeter Science Park development.
The scheme is part of a package of developments to open up access to the Exeter and East Devon Growth Point.
The area includes the Exeter Science Park and Skypark business development, which together are expected to create more than 10,000 jobs and generate around £450million in private sector investment. It also includes the Exeter Gateway (intermodal freight facility) and the new community at Cranbrook.
The new £3.75 million Redhayes Bridge, which provides access across the M5 for cyclists and pedestrians, is expected to open later this summer to link the city cycle network with the East of Exeter.